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AUNP-12 (TFA)

CAT: 0804-HY-P1812A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1812A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1].
Product Name Alternative
NP-12 (TFA)
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/np-12-tfa.html
Purity
98.03
Solubility
10 mM in DMSO
Smiles
OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCNC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C142H226N40O48.xC2HF3O2
Molecular Weight
3261.60
References & Citations
[1]Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18 (6) :1081-1091.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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