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Tigogenin (Standard)

CAT: 0804-HY-N1403RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N1403RSize:1 Each
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Description
Tigogenin (Standard) is a steroidal sapogenins. Tigogenin (Standard) can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin (Standard) can inhibit cells proliferation and induce apoptosis. Tigogenin (Standard) can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis[1][2][3][4].
CAS Number
77-60-1
UNSPSC
12352005
Target
Apoptosis; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tigogenin-standard.html
Smiles
[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]
Molecular Formula
C27H44O3
Molecular Weight
416.64
References & Citations
[1]Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270 (1-2) :17-22.|[2]Liagre B, et al. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and Tigogenin (Standard) is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. Int J Mol Med. 2007 Oct;20 (4) :451-60.|[3]Bao R, et al. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May 9;14 (9) :1983.|[4]Michalak O, et al. Synthesis and anti-tumour, immunomodulating activity of diosgenin and Tigogenin (Standard) conjugates. J Steroid Biochem Mol Biol. 2020 Apr;198:105573.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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