Tigogenin

• Description :

  Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/tigogenin.html

• Purity :

  98.0

• Solubility :

  Ethanol : 14.29 mg/mL (ultrasonic)

• Smiles :

  [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]

• Molecular Formula :

  C27H44O3

• Molecular Weight :

  416.64

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270 (1-2) :17-22.|[2]Liagre B, et al. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. Int J Mol Med. 2007 Oct;20 (4) :451-60.|[3]Bao R, et al. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May 9;14 (9) :1983.|[4]Michalak O, et al. Synthesis and anti-tumour, immunomodulating activity of diosgenin and tigogenin conjugates. J Steroid Biochem Mol Biol. 2020 Apr;198:105573.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [77-60-1]