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SPTC3 rabbit pAb

CAT: 0855-ES12971-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12971-01Size:50 µL
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Background
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]) . SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]) . There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]) .[supplied by OMIM, Nov 2010]
Description
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2. 3. 1. 50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al. 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al. 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al. 2009 [PubMed 19416851]). [supplied by OMIM, Nov 2010],
UniProt
Q9NUV7
Swiss Prot
Q9NUV7
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human SPTC3 AA range: 341-391
Target
SPTC3
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Gene ID (Human)
55304

UniProtKB · Q9NUV7

Serine palmitoyltransferase 3

SPTC3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NUV7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SPTLC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.50
Processing
—
Secondary accessions
A2A2I4, B9EK64, Q05DQ8, Q5T1U4, Q9H1L1, Q9H1Z0
Protein keywords

Molecular function

AcyltransferaseTransferase

Coding sequence diversity

Alternative splicing

Cellular component

Endoplasmic reticulumMembrane

Biological process

Lipid metabolismSphingolipid metabolism

Technical term

Proteomics identificationReference proteome

Ligand

Pyridoxal phosphate

Domain

TransmembraneTransmembrane helix

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