SDF-1α (human)

• Description :

  SDF-1α (human) is a mononuclear cells chemoattractant that can bind to CXCR4. SDF-1α plays a central role in stem cell homing, retention, survival, proliferation, cardiomyocyte repair, angiogenesis and ventricular remodelling following myocardial infarction. SDF-1α (human) can be used in cardiovascular disease research[1][2].

• CAS Number :

  [1268129-65-2]

• UNSPSC :

  12352209

• Target :

  CXCR

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/sdf-1α-human.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@H]3C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N5[C@@H](CCC5)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N6[C@@H](CCC6)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC%12=CNC=N%12)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC%13=CNC=N%13)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N%14[C@@H](CCC%14)C(N[C@H]4CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

• Molecular Formula :

  C356H578N106O93S4

• Molecular Weight :

  7959.34

• References & Citations :

  [1]Gupta SK, et al. Modulation of CXCR4 expression and SDF-1alpha functional activity during differentiation of human monocytes and macrophages. J Leukoc Biol. 1999 Jul;66 (1) :135-43. |[2]Bromage DI, et al. Stromal derived factor 1α: a chemokine that delivers a two-pronged defence of the myocardium. Pharmacol Ther. 2014 Sep;143 (3) :305-15.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Citation 01 :

  ACS Appl Mater Interfaces. 2025 Jun 18;17 (24) :34982-34996.|Chem Eng J. 2025 Sep 4;522:168081.