SIA Crosslinker

• Description :

  SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• Product Name Alternative :

  Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sia-crosslinker.html

• Purity :

  98.0

• Solubility :

  DMF : ≥ 100 mg/mL|DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(ON1C(CCC1=O)=O)CI

• Molecular Formula :

  C6H6INO4

• Molecular Weight :

  283.02

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker

• CAS Number :

  [39028-27-8]