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Octinoxate-13C, d3

CAT: 0804-HY-B1234SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1234SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Octinoxate-13C, d3 is the deuterium labeled Octinoxate. Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo[1][2][3][4][5].
UNSPSC
12352005
Target
Androgen Receptor; Cytochrome P450; Estrogen Receptor/ERR; Isotope-Labeled Compounds; Thyroid Hormone Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C(OCC(CC)CCCC)/C=C/C1=CC=C(O[13C]([2H])([2H])[2H])C=C1
Molecular Formula
C17 13CH23D3O3
Molecular Weight
294.41
References & Citations
[1]Cahova J, et al. Octinoxate as a potential thyroid hormone disruptor - A combination of in vivo and in vitro data. Sci Total Environ. 2023 Jan 15;856 (Pt 1) :159074.|[2]Schmutzler C, et al. Endocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkers. Environ Health Perspect. 2007 Dec;115 Suppl 1 (Suppl 1) :77-83.|[3]Ka Y, et al. Waterborne exposure to avobenzone and octinoxate induces thyroid endocrine disruption in wild-type and thrαa-/- zebrafish larvae[J]. Ecotoxicology. 2022 Aug;31 (6) :948-955. |[4]Phelan-Dickinson SJ, et al. The UVR Filter Octinoxate Modulates Aryl Hydrocarbon Receptor Signaling in Keratinocytes via Inhibition of CYP1A1 and CYP1B1[J]. Toxicol Sci. 2020 Sep 1;177 (1) :188-201. |[5]Chang KY, et al. Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway[J]. Toxicol In Vitro. 2023 Feb;86:105511.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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