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ID-8

CAT: 0804-HY-15838-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15838-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) . ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs[1][2].
CAS Number
147591-46-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ID-8.html
Purity
99.92
Solubility
DMSO : ≥ 47 mg/mL
Smiles
OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3
Molecular Formula
C16H14N2O4
Molecular Weight
298.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1 (1) : p. 18-28.|[2]Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72 (5) : p. 1242-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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