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ZN423 rabbit pAb

CAT: 0855-ES12162-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12162-01Size:50 µL
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Background
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Description
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 Zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012],
UniProt
Q2M1K9
Swiss Prot
Q2M1K9
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human ZN423 AA range: 848-898
Target
ZN423
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus .
Gene ID (Human)
23090

UniProtKB · Q2M1K9

Zinc finger protein 423

ZN423_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q2M1K9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZNF423
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O94860, Q76N04, Q9NZ13
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Disease

CiliopathyDisease variantJoubert syndromeNephronophthisis

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

RepeatZinc-finger

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