Thalidomide-NH-PEG2-C2-CH2

Thalidomide-NH-PEG2-C2-CH2

• CAS Number: 2064175-30-8
• UNSPSC Description: Thalidomide-NH-PEG2-C2-CH2 is a conjugate of E3 ligase ligand and linker. Thalidomide-NH-PEG2-C2-CH2 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342)[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-nh-peg2-c2-ch2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C2C=CC(NCCOCCOCCN)=C1)N(C(CC3)C(NC3=O)=O)C2=O
• Molecular Weight: 404.42
• References & Citations: [1]Li H, et al., Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS Med Chem Lett. 2024 Apr 22;15(5):631-639.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported