Thalidomide-NH-PEG2-C2-CH2

• UNSPSC Description:

  Thalidomide-NH-PEG2-C2-CH2 is a conjugate of E3 ligase ligand and linker. Thalidomide-NH-PEG2-C2-CH2 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342)[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-nh-peg2-c2-ch2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C2C=CC(NCCOCCOCCN)=C1)N(C(CC3)C(NC3=O)=O)C2=O

• Molecular Weight:

  404.42

• References & Citations:

  [1]Li H, et al., Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS Med Chem Lett. 2024 Apr 22;15(5):631-639.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2064175-30-8