Thalidomide-NH-PEG2-C2-CH2

CAT:

804-HY-158343

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CAS Number: 2064175-30-8
UNSPSC Description: Thalidomide-NH-PEG2-C2-CH2 is a conjugate of E3 ligase ligand and linker. Thalidomide-NH-PEG2-C2-CH2 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342)[1].
Target Antigen: E3 Ligase Ligand-Linker Conjugates
Type: Reference compound
Related Pathways: PROTAC
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/thalidomide-nh-peg2-c2-ch2.html
Solubility: 10 mM in DMSO
Smiles: O=C(C1=C2C=CC(NCCOCCOCCN)=C1)N(C(CC3)C(NC3=O)=O)C2=O
Molecular Weight: 404.42
References & Citations: [1]Li H, et al., Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS Med Chem Lett. 2024 Apr 22;15(5):631-639.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-158343	Thalidomide-NH-PEG2-C2-CH2
HY-130853-02	Thalidomide-NH-PEG2-C2-NH-Boc
HY-130853-01	Thalidomide-NH-PEG2-C2-NH-Boc
HY-138855	Thalidomide-NH-amido-PEG2-C2-NH2
HY-169397	Thalidomide-NH-CH2-CONH-C2-PEG-bromine
HY-131717-02	Thalidomide-NH-CH2-COOH
HY-131717-01	Thalidomide-NH-CH2-COOH
HY-138855A	Thalidomide-NH-amido-PEG2-C2-NH2 (hydrochloride)
HY-W584513	Thalidomide-NH-(CH2)2-NH-Boc
HY-W584515	Thalidomide-NH-(CH2)3-NH-Boc