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Trilaciclib (hydrochloride)

CAT: 0804-HY-101467A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101467A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trilaciclib (G1T28) hydrochloride is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib hydrochloride attenuates apoptosis and myelosuppression induced by 5FU chemotherapy[1].
CAS Number
1977495-97-8
Product Name Alternative
G1T28 (hydrochloride)
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Trilaciclib_hydrochloride.html
Purity
99.69
Solubility
H2O : 0.96 mg/mL (ultrasonic; adjust pH to 1 with 1 M HCL)
Smiles
O=C1C2=CC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=N4)N=C3N2C6(CCCCC6)CN1.[H]Cl.[H]Cl
Molecular Formula
C24H32Cl2N8O
Molecular Weight
519.47
References & Citations
[1]Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol Cancer Ther. 2016 May;15 (5) :783-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK4; CDK6

Chemical Information

Trilaciclib dihydrochloride
CAS Number1977495-97-8
PubChem CID124081865
IUPAC Name4-[[5-(4-methylpiperazin-1-yl)-2-pyridinyl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one;dihydrochloride
Molecular FormulaC24H32Cl2N8O
Molecular Weight519.5
Topological Polar Surface Area91.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count35
Formal Charge0
Complexity707
SMILES
CN1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6.Cl.Cl
InChI
InChI=1S/C24H30N8O.2ClH/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23;;/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29);2*1H
InChIKey
BRCYOXKEDFAUSA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trilaciclib dihydrochloride
CAS: 1977495-97-8
CID: 124081865
Formula: C24H32Cl2N8O
MW: 519.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight519.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass518.2076131
Monoisotopic Mass518.2076131
Topological Polar Surface Area91.2 Ų
Heavy Atom Count35
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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CED49597-01Trilaciclib hydrochloride
A22034-50Trilaciclib hydrochloride 50mg
A22034-10Trilaciclib hydrochloride 10mg
A22034-5Trilaciclib hydrochloride 5mg
A22034-100Trilaciclib hydrochloride 100mg
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A22034-200Trilaciclib hydrochloride 200mg
A22034-25Trilaciclib hydrochloride 25mg
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