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Trilaciclib (Standard)

CAT: 0804-HY-101467RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101467RSize:1 Each
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Description
Trilaciclib (Standard) is the analytical standard of Trilaciclib. This product is intended for research and analytical applications. Trilaciclib (G1T28) is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively.. Trilaciclib can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy[1].
CAS Number
1374743-00-6
Target
CDK; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C)CC6)C=C5)N=C43)CCCCC2
Molecular Formula
C24H30N8O
Molecular Weight
446.55
References & Citations
[1]Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression. Mol Cancer Ther. 2016 May;15 (5) :783-93.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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