3-(2-Hydroxyethyl) thio withaferin A

• UNSPSC Description:

  3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].

• Target Antigen:

  NF-κB

• Type:

  Natural Products

• Related Pathways:

  NF-κB

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/3-2-hydroxyethyl-thio-withaferin-a.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@H](C1OC(C(CO)=C(C)C1)=O)C2CCC3C4C[C@@H]5[C@]([C@@]6(C)C4CC[C@@]32C)(O5)[C@@H](O)[C@@H](SCCO)CC6=O

• Molecular Weight:

  548.73

• References & Citations:

  [1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported