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Withaferin A

CAT: 0804-HY-N2065-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2065-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
CAS Number
5119-48-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Ferroptosis; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Withaferin_A.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@]([C@](CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@@H]([C@@](O3)([H])CC(C)=C(CO)C3=O)C)([H])[C@@]2([H])C4)(C(C=C5)=O)[C@@]6([C@H]5O)[C@@H]4O6
Molecular Formula
C28H38O6
Molecular Weight
470.60
Precautions
H315, H319, H335
References & Citations
[1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282 (7) :4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14 (6) :623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8 (43) :74494-74505.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB

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