Chelerythrine (chloride)

CAT: 0804-HY-12048-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12048-01Size:5 mg
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Description
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
CAS Number
[3895-92-9]
UNSPSC
12352005
Hazard Statement
H300, H315, H319, H335
Target
Apoptosis; Autophagy; Bcl-2 Family; PKC
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Chelerythrine-Chloride.html
Purity
99.11
Solubility
DMSO : 4.35 mg/mL (ultrasonic)
Smiles
C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]
Molecular Formula
C21H18ClNO4
Molecular Weight
383.82
Precautions
H300, H315, H319, H335
References & Citations
[1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.|[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19 (10) :890-5. Epub 2012 May 14.|[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11 (6) :3917-3924|[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172 (3) :993-9.|[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278 (23) :20453-6.|[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKC
Citation 01
Bull Sib Med. 2025.|Cytokine. 2024 Jul 26:182:156717.|Harvard Medical School LINCS LIBRARY|Heliyon. 2024 Jul 28;10 (15) :e35368.|J Headache Pain. 2022 Mar 8;23 (1) :35.|J Inflamm Res. 2025 Mar 20:18:4213-4231.|Nutrients. 2025 Nov 12;17 (22) :3534.|Phytother Res. 2023 Oct;37 (10) :4674-4689.|Research Square Preprint. 2020 Oct.|Sci Rep. 2017 Aug 23;7 (1) :9201.|Biochem Biophys Res Commun. 2024 Oct 29:739:150914.|Cancer Cell Int. 2023 Jun 17;23 (1) :117.|Cell Commun Signal. 2021 Oct 11;19 (1) :103.|FASEB J. 2019 Dec;33 (12) :13644-13659.|Fishes. 2022, 7 (5), 229.|Front Pharmacol. 2021 May 13:12:655726.|Front Physiol. 2021 Oct 28;12:770430.|Planta Med. 2024 Jun;90 (7-08) :523-533.

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