Chelerythrine (chloride)
CAT:
804-HY-12048-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Chelerythrine (chloride)
- CAS Number: 3895-92-9
- UNSPSC Description: Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
- Target Antigen: Apoptosis; Autophagy; Bcl-2 Family; PKC
- Type: Natural Products
- Related Pathways: Apoptosis;Autophagy;Epigenetics;TGF-beta/Smad
- Field of Research: Cancer; Metabolic Disease; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/Chelerythrine-Chloride.html
- Purity: 99.42
- Solubility: DMSO : 4.35 mg/mL (ultrasonic)
- Smiles: C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]
- Molecular Weight: 383.82
- References & Citations: [1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.|[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.|[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924|[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.|[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.|[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.Cytokine. 2024 Jul 26:182:156717.|Harvard Medical School LINCS LIBRARY|Heliyon. 2024 Jul 28;10(15):e35368.|J Headache Pain. 2022 Mar 8;23(1):35.|Phytother Res. 2023 Jul 4.|Research Square Preprint. 2020 Oct.|Sci Rep. 2017 Aug 23;7(1):9201.|Biochem Biophys Res Commun. 2024 Oct 29:739:150914.|Cancer Cell Int. 2023 Jun 17;23(1):117.|Cell Commun Signal. 2021 Oct 11;19(1):103.|FASEB J. 2019 Dec;33(12):13644-13659.|Fishes. 2022, 7(5), 229.|Front Pharmacol. 13 May 2021.|Front Physiol. 2021 Oct 28;12:770430.|Planta Med. 2024 Jun;90(7-08):523-533.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported