Chelerythrine

• Description :

  Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H300-H315-H319-H335

• Target :

  Apoptosis; Autophagy; Bcl-2 Family; Beta-lactamase; PKC

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/chelerythrine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5

• Molecular Formula :

  C21H18NO4

• Molecular Weight :

  348.37

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172 (3) :993-9.|[2]Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.|[3]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278 (23) :20453-6.|[4]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.|[5]Li W, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35 (6) :1814-24. |[6]He N, et al. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018 Sep 26;18 (1) :261.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  PKC

• Citation 01 :

  Biochem Biophys Res Commun. 2024 Oct 29:739:150914.|Cancer Cell Int. 2023 Jun 17;23 (1) :117.|Cell Commun Signal. 2021 Oct 11;19 (1) :103.|FASEB J. 2019 Dec;33 (12) :13644-13659.|Fishes. 2022, 7 (5), 229.|Front Pharmacol. 2021 May 13:12:655726.|Front Physiol. 2021 Oct 28;12:770430.|Planta Med. 2024 Jun;90 (7-08) :523-533.|Bull Sib Med. 2025.|Cytokine. 2024 Jul 26:182:156717.|Harvard Medical School LINCS LIBRARY|Heliyon. 2024 Jul 28;10 (15) :e35368.|J Headache Pain. 2022 Mar 8;23 (1) :35.|J Inflamm Res. 2025 Mar 20:18:4213-4231.|Nutrients. 2025 Nov 12;17 (22) :3534.|Phytother Res. 2023 Oct;37 (10) :4674-4689.|Research Square Preprint. 2020 Oct.|Sci Rep. 2017 Aug 23;7 (1) :9201.

• CAS Number :

  [34316-15-9]