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BRD3308

CAT: 0804-HY-19618-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19618-04Size:25 mg
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Description
BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM) . BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3].
CAS Number
1550053-02-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; HDAC; HIV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/brd3308.html
Purity
98.34
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1
Molecular Formula
C15H14FN3O2
Molecular Weight
287.29
Precautions
H315, H319
References & Citations
[1]Barton KM, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014 Aug 19;9 (8) :e102684.|[2]Lundh M, et al. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes Metab. 2015 Jul;17 (7) :703-7.|[3]Wagner FF, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016 Feb 19;11 (2) :363-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HIV-1

Chemical Information

Brd3308
CAS Number1550053-02-5
PubChem CID72734382
IUPAC Name4-acetamido-N-(2-amino-4-fluorophenyl)benzamide
Molecular FormulaC15H14FN3O2
Molecular Weight287.29
XLogP1.4
Topological Polar Surface Area84.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity383
SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)N
InChI
InChI=1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
InChIKey
RRJDFENBXIEAPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Brd3308
CAS: 1550053-02-5
CID: 72734382
Formula: C15H14FN3O2
MW: 287.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.29
XLogP31.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass287.10700486
Monoisotopic Mass287.10700486
Topological Polar Surface Area84.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity383
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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