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BRD3308

CAT: 0804-HY-19618-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19618-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM) . BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3].
CAS Number
1550053-02-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; HDAC; HIV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/brd3308.html
Purity
98.34
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1
Molecular Formula
C15H14FN3O2
Molecular Weight
287.29
Precautions
H315, H319
References & Citations
[1]Barton KM, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014 Aug 19;9 (8) :e102684.|[2]Lundh M, et al. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes Metab. 2015 Jul;17 (7) :703-7.|[3]Wagner FF, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016 Feb 19;11 (2) :363-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HIV-1

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