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PA-915

CAT: 0804-HY-147557-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147557-01Size:5 mg
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Description
PA-915 (PAC1R antagonist 1) (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP) - and nerve injury-induced allodynia[1].
CAS Number
[2305204-24-2]
Product Name Alternative
PAC1R antagonist 1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PACAP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pac1r-antagonist-1.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
O=C(C1CC(N(C1)C2=NNC3=C2C=CC=C3Cl)=O)NCCC4=CNC=N4
Molecular Formula
C17H17ClN6O2
Molecular Weight
372.81
Precautions
H302, H315, H319, H335
References & Citations
[1]Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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