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Nitisinone-13C6

CAT: 0804-HY-W777526Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W777526Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nitisinone-13C6 is a 13C-labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism[1][2][3][4].
CAS Number
1246815-63-3
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nitisinone-13c6.html
Smiles
O=C([13CH]1[13C]([13CH2][13CH2][13CH2][13C]1=O)=O)C2=C(C=C(C=C2)C(F)(F)F)[N+]([O-])=O
Molecular Formula
C8 13C6H10F3NO5
Molecular Weight
335.18
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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