BFC1103

CAT: 0804-HY-161577Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-161577Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells[1].

CAS Number

701231-39-2

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bfc1103.html

Smiles

O=C(NC1=CC=C(CCCC)C=C1)CN(S(C)(=O)=O)CC2=CC=CC=C2

Molecular Formula

C20H26N2O3S

Molecular Weight

374.50

References & Citations

[1]Kopparapu P R, et al. Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis[J]. ACS Pharmacology & Translational Science, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-161276-01	BFC1108

Alternative Products

Catalog	Name
T88272-01	BFC1103

BFC1103

Related Products

Alternative Products

Popular Products