Products for Research Use Only
RegisterLogin

BFC1103

CAT: 0931-T88272-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T88272-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
701231-39-2
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
BFC1103 is a small molecule compound that primarily interacts with a specific domain of Bcl-2, particularly its loop domain. This interaction causes a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homologous 3) domain and switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of either Bax or Bak, both of which are crucial proteins in the mitochondrial-mediated intrinsic apoptosis pathway. In mouse models, BFC1103 effectively inhibited lung metastasis of triple-negative breast cancer. BFC1103 can be used to study the role of Bcl-2 family proteins in cancer development and their impact on cancer cell survival and proliferation.
Smiles
O=C(NC1=CC=C(C=C1)CCCC)CN(CC=2C=CC=CC2)S(=O)(=O)C
Molecular Formula
C20H26N2O3S
Molecular Weight
374.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N~2~-benzyl-N~1~-(4-butylphenyl)-N~2~-(methylsulfonyl)glycinamide
CAS Number701231-39-2
PubChem CID2201520
IUPAC Name2-[benzyl(methylsulfonyl)amino]-N-(4-butylphenyl)acetamide
Molecular FormulaC20H26N2O3S
Molecular Weight374.5
XLogP3.8
Topological Polar Surface Area74.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count26
Formal Charge0
Complexity516
SMILES
CCCCC1=CC=C(C=C1)NC(=O)CN(CC2=CC=CC=C2)S(=O)(=O)C
InChI
InChI=1S/C20H26N2O3S/c1-3-4-8-17-11-13-19(14-12-17)21-20(23)16-22(26(2,24)25)15-18-9-6-5-7-10-18/h5-7,9-14H,3-4,8,15-16H2,1-2H3,(H,21,23)
InChIKey
WPWRAWWSVHTACF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N~2~-benzyl-N~1~-(4-butylphenyl)-N~2~-(methylsulfonyl)glycinamide
CAS: 701231-39-2
CID: 2201520
Formula: C20H26N2O3S
MW: 374.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight374.5
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass374.16641387
Monoisotopic Mass374.16641387
Topological Polar Surface Area74.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity516
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T84314-01BFC1108

Alternative Products

CatalogName
GTR19233941-01BFC1103

Popular Products