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BFC1108

CAT: 0804-HY-161276-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161276-01Size:5 mg
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Description
BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers.[1].
CAS Number
692774-37-1
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bfc1108.html
Concentration
10mM
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=CC=CC=C1NC(C2=CC(Cl)=CC=C2NC(C3=CC=C(OC)C=C3)=O)=O
Molecular Formula
C23H21ClN2O4
Molecular Weight
424.88
References & Citations
[1]Kopparapu PR, et al. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024 Feb 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]benzamide
CAS Number692774-37-1
PubChem CID2192004
IUPAC Name5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]benzamide
Molecular FormulaC23H21ClN2O4
Molecular Weight424.9
XLogP5.1
Topological Polar Surface Area76.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity567
SMILES
CCOC1=CC=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)NC(=O)C3=CC=C(C=C3)OC
InChI
InChI=1S/C23H21ClN2O4/c1-3-30-21-7-5-4-6-20(21)26-23(28)18-14-16(24)10-13-19(18)25-22(27)15-8-11-17(29-2)12-9-15/h4-14H,3H2,1-2H3,(H,25,27)(H,26,28)
InChIKey
KSBAFMQAXIHVCL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]benzamide
CAS: 692774-37-1
CID: 2192004
Formula: C23H21ClN2O4
MW: 424.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight424.9
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass424.1189848
Monoisotopic Mass424.1189848
Topological Polar Surface Area76.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity567
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-161577BFC1103

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CatalogName
BA3215-5BFC1108

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