Methionine

• Description:

  Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

• Product Name Alternative:

  MRX-1024; D-Methionine

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/MRX-1024.html

• Concentration:

  10mM

• Purity:

  99.86

• Solubility:

  H2O : 25 mg/mL (ultrasonic)

• Smiles:

  N[C@H](CCSC)C(O)=O

• Molecular Formula:

  C5H11NO2S

• Molecular Weight:

  149.22

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna) . 2014 Jul;121 (7) :683-93.|[2]Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6 (3) :532-41.|[3]Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27 (3) :199-204.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [348-67-4]