Pipecolic acid-d9

• Description :

  Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Isotope-Labeled Compounds; YAP

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Infection

• Purity :

  99.9

• Solubility :

  H2O : 50 mg/mL (ultrasonic; warming)

• Smiles :

  OC(C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1)=O

• Molecular Formula :

  C6H2D9NO2

• Molecular Weight :

  138.21

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33 (6) :401-7.|[3]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36 (3) :200-5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  GPX4

• CAS Number :

  [790612-94-1]