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Pipecolic acid-d9

CAT: 0804-HY-Y0669S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0669S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].
CAS Number
790612-94-1
UNSPSC
12352005
Target
Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Isotope-Labeled Compounds; YAP
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection
Purity
99.9
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
OC(C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1)=O
Molecular Formula
C6H2D9NO2
Molecular Weight
138.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33 (6) :401-7.|[3]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36 (3) :200-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
GPX4

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