Pipecolic acid

• Description :

  Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].

• UNSPSC :

  12352200

• Hazard Statement :

  H315, H319, H335

• Target :

  Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; YAP

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Pipecolic_acid.html

• Purity :

  99.92

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1CCCCN1

• Molecular Formula :

  C6H11NO2

• Molecular Weight :

  129.16

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33 (6) :401-7.|[2]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36 (3) :200-5.|[3]Liying Luo, et al. "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling." Biomedicine & Pharmacotherapy 169 (2023) : 115895.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  GPX4; Human Endogenous Metabolite; Microbial Metabolite

• CAS Number :

  [535-75-1]