Pipecolic acid

• UNSPSC Description:

  Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy[1][2][3].

• Target Antigen:

  Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; YAP

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Pipecolic_acid.html

• Purity:

  98.0

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C1CCCCN1

• Molecular Weight:

  129.16

• References & Citations:

  [1]He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7.|[2]Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5.|[3]Liying Luo, et al. "Pipecolic acid mitigates ferroptosis in diabetic retinopathy by regulating GPX4-YAP signaling." Biomedicine & Pharmacotherapy 169 (2023): 115895.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  535-75-1