Chenodeoxycholic Acid-d9

Chenodeoxycholic Acid-d9

• UNSPSC Description: Chenodeoxycholic Acid-d9 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
• Target Antigen: Autophagy; Endogenous Metabolite; FXR; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Autophagy;Metabolic Enzyme/Protease;Others
• Field of Research: Metabolic Disease; Cancer
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12C(CC[C@]2([H])[C@H](C)CCC(O)=O)C3([2H])C(CC1)[C@@]4([C@](C([2H])([2H])[C@](C([2H])([2H])C4)([2H])O)([H])C([2H])([2H])[C@@]3([2H])O)C
• Molecular Weight: 401.63
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710|[3]Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92|[4]Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11.|[5]Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56|[6]Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported