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DDX21 rabbit pAb

CAT: 0855-ES16978-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16978-01Size:50 µL
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Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008],
UniProt
Q9NR30
Swiss Prot
Q9NR30
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human DDX21 AA range: 287-337
Target
DDX21
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytosol . Mitochondrion . Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292) . Interaction with WDR46 is required for localization to the nucleolus (PubMed:23848194) . Colocalizes in the cytosol with DDX1, DHX36 and TICAM1. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly (I:C) RNA ligand stimulation (By similarity) . .
Gene ID (Human)
9188

UniProtKB · Q9NR30

Nucleolar RNA helicase 2

DDX21_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NR30
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DDX21
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.13
Processing
—
Secondary accessions
B2RDL0, Q13436, Q5VX41, Q68D35
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseImmunityInnate immunityrRNA processingTranscription

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmMitochondrionNucleus

Molecular function

HelicaseHydrolaseRNA-binding

Domain

Repeat

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