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Exo2

CAT: 0804-HY-137975-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137975-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].
CAS Number
[304684-77-3]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/exo2.html
Concentration
10mM
Purity
99.57
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC(C=C(C=C1)/C=N/NC2=C3C(CCCC4)=C4SC3=NC=N2)=C1O
Molecular Formula
C18H18N4O2S
Molecular Weight
354.43
Precautions
H302, H312, H332
References & Citations
[1]Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414 (3) :471-84.|[2]Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355 (6363) :833-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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