Mal-Exo-EVC

• Description :

  Mal-Exo-EVC is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) [1].

• UNSPSC :

  12352211

• Target :

  ADC Linker

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mal-exo-evc.html

• Smiles :

  CN(C(OC(C(NCCCCCN1C(C=CC1=O)=O)=O)C2=CC=C(NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(C)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C2)=O)C

• Molecular Formula :

  C38H55N9O12

• Molecular Weight :

  829.90

• References & Citations :

  [1]Tomohiro Watanabe, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates. J Med Chem. 2024 Oct 24;67 (20) :18124-18138.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker