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EXO1-IN-1

CAT: 0804-HY-174143-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174143-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EXO1-IN-1 (Compound F684) is a potent and selective inhibitor of exonuclease 1 (EXO1) (IC50= 15.7 μM) . EXO1-IN-1 suppresses DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase PARylation, disrupts DNA repair pathways in homologous recombination-deficient (HRD) cancer cells, and selectively kills tumor cells with defects in HR genes like BRCA1/2. EXO1-IN-1 is promising for research of homologous recombination-deficient cancer (such as BRCA-related tumors) [1].
CAS Number
1111188-09-0
UNSPSC
12352100
Target
Others
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(N2CCN(C3=CC=C(NS(=O)(C4=CC=CC=C4)=O)C(C(O)=O)=C3)CC2)C=CC=C1C
Molecular Formula
C25H27N3O4S
Molecular Weight
465.56
References & Citations
[1]Wang Y, et al. Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy. ACS Chem Biol. 2025 May 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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