FP-Biotin

• Description:

  FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].

• UNSPSC:

  12352005

• Target:

  FAAH

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/fp-biotin.html

• Purity:

  99.84

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=P(F)(CCCCCCCCCC(NCCCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)=O)OCC

• Molecular Formula:

  C27H50FN4O5PS

• Molecular Weight:

  592.75

• References & Citations:

  [1]Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18 (4) :747-754.|[2]Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12 (3) :852-861.|[3]Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180 (3) :492-498.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [259270-28-5]