Pitolisant (hydrochloride)
CAT:
804-HY-12199B-01
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pitolisant (hydrochloride)
- Product Name Alternative: Ciproxidine; BF 2649
- CAS Number: 903576-44-3
- UNSPSC Description: Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
- Target Antigen: Histamine Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
- Field of Research: Neurological Disease; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/Pitolisant-hydrochloride.html
- Purity: 99.96
- Solubility: DMSO : ≥ 43 mg/mL|H2O : 100 mg/mL (ultrasonic)
- Smiles: ClC(C=C1)=CC=C1CCCOCCCN2CCCCC2.Cl
- Molecular Weight: 332.31
- References & Citations: [1]Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by LY170053 in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with CRL 40476. Br J Pharmacol. 2013 Jun;169(3):632-44.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched