KLD-12

• Description :

  KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs) . KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3].

• CAS Number :

  [800379-47-9]

• UNSPSC :

  12352209

• Target :

  Others

• Type :

  Peptides

• Related Pathways :

  Others

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/kld-12.html

• Purity :

  99.69

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  CC(C)C[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C68H122N16O19

• Molecular Weight :

  1467.79

• References & Citations :

  [1]Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29 (10) :851-858. |[2]Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. |[3]Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99 (15) :9996-10001.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported