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XMD-12

CAT: 0804-HY-15812-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15812-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XMD-12 (compound 1) is an Aurora kinase (Aurora Kinase) inhibitor with anti-tumor activity that promotes paclitaxel induced cell death. XMD-12 exhibits high selectivity and potency against Aurora A, B, and C kinases, with IC50 values of 5.6, 18.4, and 24.6 nM, respectively[1].
CAS Number
1234481-08-3
UNSPSC
12352005
Target
Aurora Kinase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=CC=C2N(C)C3=NC(NC4=CC=C(N5CCC(O)CC5)C=C4)=NC=C3N1C
Molecular Formula
C24H26N6O2
Molecular Weight
430.50
References & Citations
[1]Nicholas Kwiatkowski, et al. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol. 2012 Jan 20;7 (1) :185-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B; Aurora C

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