PI3 Kinase p85 alpha Recombinant Rabbit Monoclonal Antibody [JE04-11]

PI3 Kinase p85 alpha Recombinant Rabbit Monoclonal Antibody [JE04-11]

• Description: Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. The Pik3r1 gene locus encodes the 85 kD regulatory subunit, as well as 55 and 50 kD regulatory subunits. It used to be thought that alternative splicing of this gene resulted in three transcript variants encoding different isoforms. In fact, it has since been shown that the 55 and 50kD subunits have their own promotors within the gene locus Pik3r1. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Suppression specifically of the 85kD subunit in early murine embryoid body development results in a transient cell-cell adhesion deficiency, mediated by transient downregulation of the adhesion molecule integrin-beta1 (ITGB1).
• Product Name Alternative: GRB1 antibody p85 alpha antibody p85 antibody P85A_HUMAN antibody Phosphatidylinositol 3 kinase associated p 85 alpha antibody Phosphatidylinositol 3 kinase regulatory 1 antibody Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody Phosphatidylinositol 3-kinase regulatory subunit alpha antibody Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody PI3 kinase p85 antibody PI3 kinase p85 subunit alpha antibody PI3-kinase regulatory subunit alpha antibody PI3-kinase subunit p85-alpha antibody PI3K antibody PI3K p85 antibody PI3K regulatory subunit alpha antibody Pik3r1 antibody PtdIns 3 kinase p85 alpha antibody PtdIns-3-kinase regulatory subunit alpha antibody PtdIns-3-kinase regulatory subunit p85-alpha antibody
• Abbreviation: PIK3R1, GRB1
• CAS Number: 9000-83-3
• Swiss Prot: P27986 Human, P26450 Mouse, Q63787 Rat
• Cellular Locus: Cytoplasm, membrane, nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within
• Isotype: IgG
• Clone: JE04-11
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: Jurkat cell lysate, MCF7 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, PC-12 cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 84 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes