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Cyclamic acid-d11 (sodium)

CAT: 0804-HY-W014839SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W014839SSize:1 Each
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Description
Cyclamic acid-d11 (Sodium cyclamate-d11) sodiumis deuterium labeled Cyclamic acid (sodium) . Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5][6].
Product Name Alternative
Sodium cyclamate-d11; Cyclohexylsulfamic acid-d11 (sodium)
UNSPSC
12352211
Target
Apoptosis; Isotope-Labeled Compounds; Necroptosis
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Others
Field of Research
Cancer; Metabolic Disease
Smiles
O=S(NC1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H])(O[Na])=O
Molecular Formula
C6HD11NNaO3S
Molecular Weight
212.29
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63 (Pt 3) :418-25.|[3]Knowles MA, Jani H, Hicks RM. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7 (5) :767-74.|[4]Chen Z, et al. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :507-511.|[5]Brantom PG, et al. Long-term toxicity of sodium cyclamate in mice. Food Cosmet Toxicol. 1973 Oct;11 (5) :735-46.|[6]Usami M, et al. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm Metab Res. 1980 Dec;12 (12) :705-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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