Products for Research Use Only
RegisterLogin

Cyclamic acid

CAT: 0804-HY-B0541-01Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0541-01Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].
CAS Number
100-88-9
Product Name Alternative
Cyclohexylsulfamic acid; Cyclamate
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cyclamic-acid.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=S(O)(NC1CCCCC1)=O
Molecular Formula
C6H13NO3S
Molecular Weight
179.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63 (Pt 3) :418-25.|[2]Chen Z, et al. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :507-511. |[3]Bopp BA, et al. Toxicological aspects of cyclamate and cyclohexylamine. Crit Rev Toxicol. 1986;16 (3) :213-306.|[4]Usami M, et al. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm Metab Res. 1980 Dec;12 (12) :705-6.|[5]Knowles MA, et al. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7 (5) :767-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-140589Acid-PEG4-S-PEG4-acid
HY-140112-01Acid-PEG2-SS-PEG2-acid
HY-140113-01Acid-PEG3-SS-PEG3-acid
HY-W096114-01Acid-PEG8-S-S-PEG8-acid
HY-140114-01Acid-PEG4-S-S-PEG4-acid
HY-N8563Masticadienonic acid
HY-N8543Gliocladic acid
HY-N17650Salviamarinic acid A
HY-N16388α-Costic acid
HY-N15317-01Phocaecholic acid

Alternative Products

CatalogName
268801-01Cyclamic acid
007245Cyclamic Acid-d11
A12756-1000Cyclamic Acid 1000mg
A12756-500Cyclamic Acid 500mg

Popular Products