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VT-105

CAT: 0804-HY-163644-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163644-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VT-105 is a TEAD inhibitor and VT104 analog. VT-105 binds to the central hydrophobic pocket of the TEAD3 protein. VT-105 can be used in the research of NF2-deficient malignant mesothelioma[1][2].
CAS Number
2417718-38-6
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vt-105.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@@H](C1=CC=CC=N1)NC(C2=CC3=C(N=C2)C(C4=CC=C(C=C4)C(F)(F)F)=CC=C3)=O
Molecular Formula
C24H18F3N3O
Molecular Weight
421.41
References & Citations
[1]Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20 (6) :986-998.|[2]Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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