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VT-1598

CAT: 0804-HY-123777-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123777-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris[1][2]. VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2089320-99-8
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vt-1598.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(COC2=CC=C(C#CC3=CC=C(C(F)(F)[C@@](O)(C4=CC=C(F)C=C4F)CN5N=NN=C5)N=C3)C=C2)C=C1
Molecular Formula
C31H20F4N6O2
Molecular Weight
584.52
References & Citations
[1]Nathan P Wiederhold, et al. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2019 Feb 26;63 (3) :e02233-18.|[2]Timothy J Break, et al. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. J Antimicrob Chemother. 2018 Aug 1;73 (8) :2089-2094.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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