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KDM5B ligand 2

CAT: 0804-HY-158433Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158433Size:1 Each
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Description
KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653.
UNSPSC
12352005
Target
Histone Demethylase; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdm5b-ligand-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2NC(C3=CC=C(C=C3)OCC(O)=O)=CC(N2N=C1)=O
Molecular Formula
C15H10N4O4
Molecular Weight
310.26
References & Citations
[1]Guan T, et al., Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer. Eur J Med Chem. 2024 May 10;272:116494.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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