DNP-PEG4-DBCO

• Description :

  DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dnp-peg4-dbco.html

• Purity :

  97.00

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCCC(N1C(C=CC=C2)=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCNC4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O

• Molecular Formula :

  C35H39N5O10

• Molecular Weight :

  689.71

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PEG Linkers

• CAS Number :

  [2149585-17-9]