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IMP-1710

CAT: 0804-HY-138995-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138995-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis[1].
CAS Number
2383117-96-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/imp-1710.html
Purity
99.67
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(CCC1)C#N)N2C3=CC=CC(C(C4=C5)=CNC4=NC=C5C#C)=C3CC2
Molecular Formula
C23H19N5O
Molecular Weight
381.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Panyain N, et, al. Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity. J Am Chem Soc. 2020 Jul 15;142 (28) :12020-12026.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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