IMP-1710

• Description :

  IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Deubiquitinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/imp-1710.html

• Purity :

  99.67

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C([C@H]1N(CCC1)C#N)N2C3=CC=CC(C(C4=C5)=CNC4=NC=C5C#C)=C3CC2

• Molecular Formula :

  C23H19N5O

• Molecular Weight :

  381.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Panyain N, et, al. Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity. J Am Chem Soc. 2020 Jul 15;142 (28) :12020-12026.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2383117-96-0]