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Yoda 1

CAT: 0804-HY-18723-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18723-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF) . Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation[1][2][3].
CAS Number
448947-81-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; ERK; Piezo Channel; Potassium Channel
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GlyT2-IN-1.html
Purity
99.97
Solubility
DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 5 mg/mL (ultrasonic) |Methanol : 2.5 mg/mL (ultrasonic)
Smiles
ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1
Molecular Formula
C13H8Cl2N4S2
Molecular Weight
355.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Syeda R, et al. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4.|[2]Dela Paz NG, et al. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497 (1) :220-225. |[3]Kuriyama M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022 Apr 15;12 (1) :6322.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

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