(1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc

(1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc

• UNSPSC Description: (1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (1r,4r)-Thalidomide-piperidine-N(Me)-CH-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/1r-4r-thalidomide-piperidine-n-me-ch-cyclohexane-nh-boc.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(CCC1N2C(C3=C(C=CC(N4CCC(CC4)N(C)C[C@H]5CC[C@@H](CC5)NC(OC(C)(C)C)=O)=C3)C2=O)=O)=O
• Molecular Weight: 581.70
• References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.|[3]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported