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16α-Hydroxyprednisolone

CAT: 0804-HY-117580-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-117580-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22 (R) epimer of the glucocorticoid Budesonide. 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily[1][2].
CAS Number
13951-70-7
Product Name Alternative
OH-PRED
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/16α-hydroxyprednisolone.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@](O)([C@@H](C[C@]4([C@@]3(CCC2=C1)[H])[H])O)C(CO)=O)C)O)[H])C
Molecular Formula
C21H28O6
Molecular Weight
376.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Xavier Matabosch, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404 (2) :325-40.|[2]G Jönsson, et al. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos. 1995 Jan;23 (1) :137-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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