16,16-Dimethyl prostaglandin A1

• UNSPSC Description:

  16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems[1][2].

• Target Antigen:

  DNA/RNA Synthesis; HIV; HSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/16-16-dimethyl-prostaglandin-a1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)CCCCCCC(O)=O

• Molecular Weight:

  364.52

• References & Citations:

  [1]K V Honn, et al. Prostaglandin analogs as inhibitors of tumor cell DNA synthesis. Proc Soc Exp Biol Med. 1981 Apr;166(4):562-7. |[2]M Hughes-Fulford, et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct;36(10):2253-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  41692-24-4