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Ulefnersen (sodium)

CAT: 0804-HY-147410A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147410A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ulefnersen sodium (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen sodium can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen sodium can be used in the research of Amyotrophic Lateral Sclerosis (ALS) [1].
CAS Number
2589926-27-0
Product Name Alternative
ION-363 (sodium)
UNSPSC
12352208
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ulefnersen-sodium.html
Purity
98.47
Solubility
H2O : ≥ 25 mg/mL
Smiles
[Ulefnersen(sodium)]
Molecular Formula
C230H302N68O126P19S13Na19
Molecular Weight
7060 (free acid)
Precautions
H302, H315, H319, H335
References & Citations
[1]Korobeynikov VA, Lyashchenko AK, Blanco-Redondo B, Jafar-Nejad P, Shneider NA. Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis. Nat Med. 2022;28 (1) :104-116.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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