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Ulefnersen

CAT: 0804-HY-147410-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147410-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) [1].
CAS Number
2589926-25-8
Product Name Alternative
ION-363
UNSPSC
12352208
Target
DNA/RNA Synthesis
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ulefnersen.html
Purity
99.22
Solubility
10 mM in DMSO
Smiles
[Ulefnersen]
Molecular Formula
C230H321N68O126P19S13
Molecular Weight
7059.72
References & Citations
[1]Korobeynikov VA, et al. Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis. Nat Med. 2022;28 (1) :104-116.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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CatalogName
GTR19233834-01Ulefnersen sodium

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