Mps1-IN-3 (hydrochloride)

• UNSPSC Description:

  Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model[1].

• Target Antigen:

  Mps1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mps1-in-3-hydrochloride.html

• Purity:

  98.04

• Solubility:

  DMSO : ≥ 20 mg/mL

• Smiles:

  OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl

• Molecular Weight:

  574.09

• References & Citations:

  [1]Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2989453-29-2